Get Advances in Immunology, Vol. 59 PDF

By Frank J. Dixon (Ed.)

ISBN-10: 0120224593

ISBN-13: 9780120224593

With contributions from Steven A. Porcelli and different across the world famous leaders within the box, this quantity maintains the culture of critical stories. Papers at the CD1 kin, confident number of thymocytes, and molecular and mobile facets of XLA spotlight the newest quantity.

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Additional resources for Advances in Immunology, Vol. 59

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Filled boxes indicate predicted 8 strands of 8-pleated sheet structure, and hatched boxes indicate predicted a-helical regions. Predictions were carried out on the CD1 a 2 domain amino acid sequences using the Protean module of the Lasergene software package (DNASTAR, Madison, WI). Chou-Fasman predictions were done using the alp class method (a threshold 103, 8 threshold 105)(Chou and Fasman, 1978). , 1978). , 1987). , 1994). Another noteworthy feature of CD1 proteins that may point to structural differences compared to MHC class I and I1 relates to their relative hydrophobicity.

1991). Another mAb against human C D l d has been produced by immunization of mice with a bacterial fusion protein corresponding to the human C D l d heavy chain. 2, reacts exclusively with denaturated CDld protein (Bilsland and Milstein, 1991). Because of the relatively large number of mAbs that have been generated against CDl, it has been possible to map specific serologically defined epitopes on these proteins by cross-inhibition studies. This approach confirms that the CDla, -b, and -c proteins as defined by mouse monoclonal antibodies are serologically very distinct.


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Advances in Immunology, Vol. 59 by Frank J. Dixon (Ed.)

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