By Frederick Rowe Davis
Davis examines the historical past of pesticide improvement along the evolution of the technology of toxicology and tracks laws governing publicity to chemical compounds around the 20th century. He affirms the brilliance of Carson’s cautious clinical interpretations drawing on information from collage and executive toxicologists. even though Silent Spring instigated laws that effectively terminated DDT use, different warnings have been missed. satirically, we changed one poison with even extra poisonous ones. Davis concludes that we urgently want new pondering how we overview and keep an eye on insecticides in accounting for his or her ecological and human toll.
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Extra info for Banned: A History of Pesticides and the Science of Toxicology
A. Fisher, the great English biostatistician who developed and promoted the use of statistics in biology. Bliss had published a seminal paper, “The Calculation of the DosageMortality Curve,” in which he demonstrated the sigmoid character of the typical dosage-mortality curve as established by numerous toxicological studies of a large number of organisms by many biologists. Acknowledging his debt to R. A. Fisher and the trends in biostatistics Fisher inspired, Bliss selected his procedures on the basis of their statistical accuracy and efﬁciency.
In the most problematic cases, 21 toxic ol o gy emerges in public health crises doctors had either no names or ﬁctitious names for individuals who received the drug. Massengill salesmen also proved hard to locate, and at least one went to jail rather than cooperate with the FDA ofﬁcials. Most doctors and pharmacists contributed willingly to the conﬁscation campaign, but a few refused to cooperate and even denied the adverse effects of the drug. One South Carolina doctor admitted to inspectors that he had dispensed just under two pints of the elixir to three white patients and two black patients, none of whom died.
Note: Gross rejected ethylene glycol and diethylene glycol on the grounds that the two compounds were too volatile rather than for their toxicity (see below for detailed discussion of diethylene glycol and the Elixir Sulfanilamide tragedy) Finally, Gross settled on Lyndol, which was a mixture of TOCP. When it passed the volatility test, Gross asked the chemical wholesaler about its toxicity. The wholesaler relayed this question to the Celluloid Corporation, which produced Lyndol, and the chemical company noted that it was presumably nontoxic.
Banned: A History of Pesticides and the Science of Toxicology by Frederick Rowe Davis